Máster Universitario en Biotecnología y Bioingeniería

Dra. Mª Isabel González Álvarez

Department: Departamento Ingeniería. Área de Farmacia y Tecnología Farmacéutica
Phone: + 34 96 591 9217
Email: isabel.gonzalez@goumh.umh.es
Current Position: Prof. Contratado Doctor of Pharmaceutics and Pharmacokinetics, Universidad Miguel Hernandez.
Research Fields:

  1. In vitro models of biological barriers for ADME predictions.
  2. Biopharmaceutical optimization and Pharmacokinetic evaluation in preclinical models,
  3. Excipients effects in oral drug absorption
  4. Bioavailability, Bioequivalence. In vivo predictive Dissolution methods for IVIVC.
Representative Publications:
  • Lozoya-Agullo I, Zur M, Wolk O, Beig A, González-Álvarez I, González-Álvarez M, Merino-Sanjuán M, Bermejo M, Dahan A. In-situ intestinal rat perfusions for human Fabs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches. Int J Pharm. 2015. 480(1-2):1-7.
  • Mangas-Sanjuan V, González-Álvarez I, González-Álvarez M, Casabó VG, Bermejo M. Modified nonsink equation for permeability estimation in cell monolayers: comparison with standard methods. 2014. Mol. Pharm. 11(5):1403-14.
  • Guillermo Rodríguez-Berna, Víctor Mangas-Sanjuán, Marta Gonzalez-Alvarez, Isabel Gonzalez-Alvarez, Jose Luis García-Gimenez, María Jose Díaz Cabanas, Marival Bermejo, Avelino Corma. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. 2014. European Journal of Medicinal Chemistry 83:366-373.
  • Mangas-Sanjuan, Victor; Gonzalez-Alvarez, Isabel; Gonzalez-Alvarez, Marta; Bermejo; Marival. Innovative in Vitro Method To Predict Rate and Extent of Drug Delivery to the Brain across the Blood-Brain Barrier. 2013. Molecular Pharmaceutics 10(10): 3822-3831.
  • Samiei N, Mangas-Sanjuan V, González-Álvarez I, Foroutan M, Shafaati A, Zarghi A, Bermejo M Source. Ion-pair strategy for enabling amifostine oral absorption: Rat in situ and in vivo experiments. Eur J Pharm Sci. 2013. 49(4):499-504.
  • Navarro, C; González-Álvarez, I; González-Álvarez, M; Manku, M; Merino, M; Casabó,VG; Bermejo, M. Influence of polyunsaturated fatty acids on Cortisol transport through MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model. Eur J Pharm Sci. 2011. 42(3):290-9.
  • Prieto P, Hoffmann S, Tirelli V, Tancredi F, González I, Bermejo M, De Angelis I. An Exploratory Study of Two Caco-2 Cell Models for Oral Absorption: A Report on Their Within-laboratory and Between-laboratory Variability, and Their Predictive Capacity. Altern Lab Anim. 2010. 38(5):367-86.


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Máster Universitario en Biología Molecular y Bioingeniería

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